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. 2016 Jul 25;7(37):59652–59663. doi: 10.18632/oncotarget.10831

Figure 4. IL-11 induces EMT in ATC cells via the PI3K/Akt/GSK3β signaling pathway.

Figure 4

A. Western blotting to detect the expression of EMT markers in FRO cells treated with rhIL-11 at increasing concentrations (0–100 ng/ml) and in sw579 cells expressing either IL-11 shRNA or the NC. B. Western blotting to detect EMT and Akt/GSK3β pathway markers in FRO cells treated with rhIL-11 for increasing amounts of time (0–60 minutes) and in sw579 cells expressing either IL-11 shRNA or NC. C. Western blotting to detect EMT and Akt/GSK3β pathway markers in sw579 cells after pretreatment with 20 μM Akt inhibitor V or LY294002 or 100 ng/ml rhIL-11 for 60 min. β-Actin was used as a loading control.