Figure 3. Determination of possible cross resistances of enzalutamide resistant cell lines with abiraterone or bicalutamide.

Proliferation A. and viability B. in DuCaP, LAPC4 and LNCaP Abl vehicle and enzalutamide resistant cell lines after 6 days of exposure to 8 μM abiraterone or 10 μM bicalutamide was measured by ³[H]thymidine incorporation assay and WST assay, respectively. Ethanol was used as control. Data represent mean +SEM from at least 3 independent experiments. *;p=<0.05. **;p=<0.01. ***;p=<0.001