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. 2016 Jul 29;7(37):59781–59794. doi: 10.18632/oncotarget.10926

Figure 6. Enzalutamide resistant LAPC4 acquired AR gene amplification.

Figure 6

A. AR gene amplification was determined by duplex qPCR of genomic DNA amplifying an AR Exon 1 fragment (Chr Xq12) in relation a POLG Exon 3 fragment (Chr 15q25). AR/POLG copy number ratios were calculated as fold change of normal male DNA which harbors 1 copy of AR. Data represent mean +SEM from 3 independent PCR analyses. *;p=<0.05 B. Analysis of AR gene amplification over time during generation of enzalutamide resistant LAPC4 cells starting from parental LAPC4. P = Passage.