Table 2. Univariate association of 17-3′UTR-classifier, clinicopathological variables, and single 3′UTR ERI with event-free survival.

	Training set (n=164)		Validation set (n=163)
	HR (95% CI)	p-value	HR (95% CI)	p-value
Age (>50 years vs ≤50 years)	1.17 (0.69-1.96)	0.56	1.01 (0.60-1.70)	0.96
Lymph node status (negative vs positive)	1.95 (1.06-3.60)	0.032	1.80 (1.02-3.19)	0.044
Tumor size (≤2 cm vs >2 cm)	1.10 (0.60-2.01)	0.76	1.51 (0.78-2.91)	0.22
CLIC2 3′UTR	0.52 (0.28-0.96)	0.036	0.61 (0.36-1.03)	0.063
CXCL8 3′UTR	0.61 (0.45-0.84)	0.0021	0.72 (0.54-0.97)	0.032
PPIC 3′UTR	0.32 (0.15-0.68)	0.0030	0.55 (0.25-1.23)	0.15
PRCKB 3′UTR	0.47 (0.27-0.80)	0.0055	0.60 (0.34-1.06)	0.077
RTN1 3′UTR	0.38 (0.16-0.91)	0.030	0.39 (0.17-0.86)	0.019
SMAD6 3′UTR	0.48 (0.29-0.81)	0.0062	0.72 (0.47-1.09)	0.12
ZCCHC14 3′UTR	0.55 (0.33-0.91)	0.021	0.70 (0.43-1.13)	0.15
ADGRL2 3′UTR	3.04 (1.34-6.91)	0.0080	2.37 (1.09-5.14)	0.030
N4BP2L2 3′UTR	2.77 (1.52-5.05)	0.00092	1.70 (0.91-3.18)	0.099
NPL 3′UTR	1.80 (1.00-3.22)	0.048	1.70 (0.98-2.96)	0.061
PRSS12 3′UTR	1.89 (0.80-4.49)	0.15	2.27 (1.20-4.30)	0.012
SCL2A3 3′UTR	2.20 (1.31-3.67)	0.0027	1.61 (0.96-2.68)	0.068
SIK3 3′UTR	2.34 (1.18-4.67)	0.015	1.92 (0.94-3.94)	0.073
SYNGR1 3′UTR	1.72 (0.93-3.18)	0.084	2.36 (1.26-4.42)	0.0072
UBE2G2 3′UTR	1.73 (0.98-3.04)	0.057	1.63 (1.01-2.64)	0.046
WDHD1 3′UTR	7.56 (2.01-28.6)	0.0028	3.01 (0.70-12.9)	0.14
ZER1 3′UTR	3.20 (1.32-7.75)	0.0099	1.76 (0.84-3.70)	0.13
17-3′UTR-based classifier	8.73 (5.05-15.1)	<0.0001	3.22 (2.10-4.94)	<0.0001
17-3′UTR-based classifier (low vs high risk)	8.29 (4.78-14.4)	<0.0001	3.17 (1.86-5.42)	<0.0001