Figure 1. Schematic of autocatalytic, tumor-targeted delivery of nanoparticles by 3E10^EN.

A. Schematics of PLGA nanoparticles with surface conjugation of 3E10^EN for exDNA targeting and with internally encapsulated DOX. B, C. Mechanism of autocatalytic, tumor-targeted delivery of nanoparticles. 3E10^EN has the ability to home nanoparticles to tumors, which contain a greater amount of exDNA than healthy tissue (B). The concentration of exDNA in tumor environments is expected to further increase with time and delivery of cytotoxic therapy, such as DOX. Therefore, the efficiency of nanoparticle accumulation in tumors autocatalytically increases with time and subsequent treatments (C).