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. 2016 Aug 4;7(37):60074–60086. doi: 10.18632/oncotarget.11054

Figure 1. Expression of miR-181c is associated with chemoresistance in chronic myelocytic leukemia.

Figure 1

A. Comparison of miRNA expression in K562/ADR and its parental cells by using the Exiqon Human miRNA microarray. Expression levels of miR-181c in K562 cells were higher than those in K562/ADR cells. B. A validation experiment was carried out using qRT-PCR. The relative levels were normalized to U6 snRNA. Expressions of miR-181c in parental K562, KCL22 and KU812 cells were higher compared to their ADR-resistant cells (*p<0.05). C. Moreover, chemoresistant cancer samples have significantly lower levels of miR-181c (*p<0.05).