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. 2016 Aug 4;7(37):60074–60086. doi: 10.18632/oncotarget.11054

Figure 2. Knockdown of miR-181c promotes drug resistance in vitro.

Figure 2

A. qRT-PCR was performed to measure miR-181c levels in K562 cells transfected with the antagomir control or antagomiR-181c. Decreased miR-181c levels were observed in the antagomiR-181-transfected cells compared to the control (*p<0.05). B. K562 cells were treated with ADR, VCR and Taxol for 48 h. Cell viability was determined using a CCK8 assay. More cells survived in antagomiR-181c-transfected group (*p<0.05). C. Knockdown of miR-181c increased IC50 values of K562 cells to ADR, VCR, and Taxol (*p<0.05). D. K562 cells were treated with ADR, VCR and Taxol, followed by analysis of apoptosis. There were fewer cells undergoing apoptosis in the antagomiR-181-transfected group (*p<0.05).