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. 2016 Aug 4;7(37):60074–60086. doi: 10.18632/oncotarget.11054

Figure 3. Upregulation of miR-181c decreases cell chemoresistance in vitro.

Figure 3

A. qRT-PCR was performed to measure miR-181c levels in K562/ADR cells transfected with the mimic control or miR-181c. Increased miR-181c levels were observed in the miR-181-transfected cells compared to the control (*p<0.05). B. K562/ADR cells were treated with ADR, VCR and Taxol for 48 h. Cell viability was determined using a CCK8 assay. Lower cells survived in miR-181c-transfected group (*p<0.05). C. Ectopic expression of miR-181c sensitized K562/ADR cells to ADR, VCR and Taxol (*p<0.05). D. K562/ADR cells were treated with ADR, VCR and Taxol, followed by analysis of apoptosis. There were more cells undergoing apoptosis in the miR-181c-transfected group (*p<0.05).