Table 6. Hazard of dying after diagnosis with colorectal cancer associated with any miRNA expression in carcinoma tissue for miRNAs not commonly expressed previously reported in the literature.
Study | miRNA | % expressing | HR | 95% (CI) | p value | FDR q value |
---|---|---|---|---|---|---|
Colon | ||||||
hsa-miR-145-3p | 1.9 | 3.36 | (2.02, 5.59) | < 0.00001 | 0.0008 | |
hsa-miR-31-5p | 17.2 | 1.70 | (1.32, 2.19) | 0.00004 | 0.0053 | |
hsa-miR-570-3p | 2.5 | 0.33 | (0.12, 0.89) | 0.02859 | 0.3958 | |
Rectal | ||||||
hsa-miR-151a-3p | 33.8 | 0.74 | (0.57, 0.97) | 0.02608 | 0.1013 | |
hsa-miR-224-5p | 10.0 | 0.66 | (0.49, 0.90) | 0.00785 | 0.0875 | |
hsa-miR-335-5p | 6.1 | 0.28 | (0.13, 0.64) | 0.00242 | 0.0875 | |
hsa-miR-374a-5p | 23.0 | 0.47 | (0.33, 0.68) | 0.00006 | 0.0070 |
1Hazard Ratios (HR) and 95% Confidence Intervals (CI) adjusted for age, sex, AJCC stage, and MSI tumor status.