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. 2016 Aug 3;7(37):60383–60394. doi: 10.18632/oncotarget.11039

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Copyright: © 2016 Posselt et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Double staining for FoxP3+ and CD8+ in tumour stroma with highlighted direct cell-to-cell interactions (arrows, 200x original magnification) and a direct FoxP3+ to CD8+ interactions at higher magnification, bottom right A. Example for the calculation of the shortest distance between FoxP3+ and CD8+ cells (orange arrows) and CD8+ to FoxP3+ (green arrows) B. Cell-to-cell distances (μm) in the biopsy, the central tumour area and the invasive front C. CD8+-FoxP3+/FoxP3+-CD8+ ratio in preRCT biopsies and post RCT central tumour and invasive front D. Epithelial/stromal ratio of FoxP3+-CD8+ and CD8+-FoxP3+ distances E. Ratio of preRCT biopsies, central tumour and invasive front of epithelial and stromal FoxP3+-CD8+ and CD8+-FoxP3+ distances F.