Skip to main content
. 2016 Jul 29;7(37):60395–60406. doi: 10.18632/oncotarget.10939

Figure 6. Signaling of OSM decreases SLUG expression in LAC.

Figure 6

A. In tumor microenvironment, autocrine or paracrine factors, including EGF and IL-6, from surrounded stromal or immune cells activate intrinsic growth factor- or cytokine- associated receptors tyrosine kinases, and downstream kinases which, in turn, phosphorylate STAT3 [28, 29]. Phosphorylated STAT3 translocate to nucleus and bind on SLUG promoter to maintain the expression of SLUG gene. B. OSM activates STAT1 and STAT3 via binding to OSM receptor (OSMR) and gp130 complex. The phosphorylated STAT1 translocate to the nucleus, bind to PIAS4 and HDAC1, and bind at SLUG promoter region. Acetylation of Histone 3 Lysine 9 (H3K9Ac) near this region was removed by HDAC1, resulting in silence the expression of SLUG gene. Phosphorylated STAT3 translocate to the nucleus, but it was blocked the binding on SLUG promoter region by PIAS3.