Figure 5. Lin28A promotes tumor growth of ER-/Her2+ breast cancer in vivo.
We injected 2×106/100ul Lin28A siRNA MDA-MB-453 cells or control cells and Lin28A SK-BR-3 cells or control cells into subcutaneous of female nude mice. A. Mice tumors which injected with Lin28A siRNA MDA-MB-453 cells exhibited significantly lower rates of incidence and growth of tumors compared to control cells(Left: tumor growth curve graph; Right: mice and tumor). B. Mice tumors injected with Lin28A SK-BR-3 cells exhibited significantly higher tumors growth compared to control cells(Left: tumor growth curve graph; Right: mice and tumor). C, D. Total RNA extracts from the tumors were examined for expression levels of Lin28A and AR. Lin28A was correlated positively with expression levels of AR in ER-/Her2+ breast tumor.