Figure 6. The expression of Lin28A, AR, and Ki67 in xenograft tumor was detected by using immunohistochemistry.
Breast cancer cells were inoculated in the left inguinal mammary fat pad of syngeneic Balb/c mice, and the mice were divided into four groups. In mice tumors which injected with MDA-MB-453 cells, Lin28A siRNA group showed downregulation of Lin28A A., AR B. and Ki67 C. expression compared with the control group D, E, F. In mice tumors which injected with SK-BR-3 cells, Lin28A group induced upregulation of Lin28A G., AR H. and Ki67 I. expression compared to the control group J, K, L.