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AZA, but not DAC, induces markers of DNA damage and apoptosis in NSCLC cell lines. A549 and H1299 cells were treated with AZA or DAC (0–10 µM) for 48 hours and Western blotting of cell extracts was used to detect DNMT1, cleaved-PARP, phospho-histone-H2AX(ser139), and total histone-H2AX. alpha-tubulin was used as a loading control.
Abbreviations: AZA, azacitidine; DAC, decitabine; DNMT1, DNA methyltransferase 1; NSCLC, non-small cell lung cancer.
