Table 2.
Hydrogen bonds in TLR2-liganded complexes are mostly mediated by the peptide chain. The table lists the number of hydrogen bonds with the main chain (first number) and the side chains (second number). n.d. stands for not determined.
*Pam2CSK4 is bound to mouse proteins. All other models involve human proteins.
| TLR2/TLR1 |
TLR2/TLR6 | ||
|---|---|---|---|
| Lipid chains binding mode | Both chains in TLR2 | One chain in each receptor | Both chains in TLR2 |
| RPR 120535 | 3/0 | 3/2 | 4/0 |
| RPR 128506 | 5/1 | 2/1 | 1/0 |
| RPR 120525 | 3/0 | 3/3 | 3/0 |
| Pam2CSK4* | n.d | n.d | 4/0 |
| Pam3CSK4 | n.d | 2/2 | n.d |