Figure 5.

AAV8BP2 targets the ganglion cells by intravitreal delivery. eGFP expression at different viral titers: 1E + 11 vg (a and b) and 1E + 12 vg (c and d) post injection with AAV8BP2. IVI led to expression in the ganglion cell axons in the optic nerve (b and d), foveal ganglion cells (e), ciliary body (f), and cornea (arrow; g). (h) is a hematoxylin and eosin–stained section of the corneal region shown transduced in (g; arrow). The asterisk indicates the iris in (g) and (h). eGFP fluorescence is seen in green, and DAPI-stained nuclei are shown in magenta. Scale bars represent 50 μm. Color images available online at www.liebertpub.com/hum