Figure 6.

Transduction in the nerve fibers of the visual pathway. Images of horizontal sections of the lateral geniculate nucleus (LGN) of the NHP brain after IVI of AAV7m8 (a–d). Nissl staining illustrating the various (1–6) LGN layers (a). eGFP expression (green) is seen in layers 1 and 2 of the LGN (b), and further magnification (of the image in the inset) indicates expression in the nerve fibers (c and d). The optic tract also contained eGFP positive nerve fibers (e). AAV8BP2-injected animals had eGFP in the nerve fibers of the optic tract (f). Scale bars represent 50 μm. Color images available online at www.liebertpub.com/hum