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. 2017 Feb 12;12:58–69. doi: 10.1016/j.redox.2017.02.007

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Nrf2 and AMPK interplay. Panel A shows the effect of MF alone in vivo in comparison to controls. Notably the increase in ZO-1 and Glut-1 in relation to Nrf2 was reproduced in mBMEC cells using sulforaphane (Panel B). Further, a dose dependent increase in NQO-1, Glut-1 and ZO-1 was observed with MF (0–40 µM) treatment in mBMEC cells by immunofluorescence imaging (Panel C). Compound C pre-treatment did not inhibit the upregulation of Nrf2 upon MF treatment in mBMEC cells as shown in the immunofluorescence images (Panel D).