Table 2.

Correlations between the products of APP processing in FAD mutation carriers

	CSF biomarker	sAPPα	sAPPβ	Aβ38	Aβ40	Aβ42
MC	sAPPα		0.87 (<0.01)	0.2 (0.4)	0.09 (0.7)	-0.2 (0.4)
	sAPPβ	0.87 (<0.01)		0.2 (0.3)	0.1 (0.6)	-0.2 (0.5)
	Aβ38	0.2 (0.4)	0.2 (0.3)		0.93 (<0.0001)	0.44 (0.06)
	Aβ40	0.09 (0.7)	0.1 (0.6)	0.93 (<0.0001)		0.6 (0.01)
	Aβ42	-0.2 (0.4)	-0.2 (0.5)	0.44 (0.06)	0.6 (0.01)
APPswe	sAPPα			0.2 (0.6)	0.2 (0.7)	-0.03 (0.9)
	sAPPβ	n.a.	n.a.	n.a.	n.a.	n.a.
	Aβ38	0.2 (0.6)			0.9 (<0.001)	0.7 (0.06)
	Aβ40	0.2 (0.7)		0.9 (<0.001)		0.8 (0.01)
	Aβ42	-0.03 (0.9)		0.7 (0.06)	0.8 (0.01)
PSEN1	sAPPα		0.66 (0.18)	0.20 (0.7)	0.20 (0.7)	0.086 (0.9)
	sAPPβ	0.66 (0.18)		0.60 (0.2)	0.60 (0.2)	0.54 (0.3)
	Aβ38	0.20 (0.7)	0.60 (0.2)		1 (<0.01)	0.83 (0.06)
	Aβ40	0.20 (0.7)	0.60 (0.2)	1 (<0.01)		0.83 (0.06)
	Aβ42	0.086 (0.9)	0.54 (0.3)	0.83 (0.06)	0.83 (0.06)
NC	sAPPα		0.64 (<0.01)	0.71 (<0.01)	0.72 (<0.01)	0.65 (<0.01)
	sAPPβ	0.64 (<0.01)		0.28 (0.3)	0.33 (0.2)	0.29 (0.3)
	Aβ38	0.71 (<0.01)	0.28 (0.3)		0.98 (<0.0001)	0.95 (<0.0001)
	Aβ40	0.72 (<0.01)	0.33 (0.2)	0.98 (<0.0001)		0.98 (<0.0001)
	Aβ42	0.65 (<0.01)	0.29 (0.3)	0.95 (<0.0001)	0.98 (<0.0001)

Correlations between the products of APP processing in the mutation carrier group as a whole (MC), carriers of the APPswe and PSEN1 mutations separately and in the nonmutation carriers (NC)

Numbers represent Pearson/Spearman correlation coefficients (p values) (significant correlations in italics)

APP amyloid precursor protein, FAD familial Alzheimer’s disease, Aβ amyloid beta, MC mutation carriers, NC noncarriers