Fig. 3.

Aprepitant treatment prevents B. burgdorferi-induced increases in CCL2 and CXCL13 mRNA expression in the dorsal root ganglia of NHPs. Rhesus macaques were uninfected (n = 5 animals) or infected intrathecally with B. burgdorferi (Bb, 1 × 10⁸ bacteria; n = 15), and were untreated (n = 7) or treated with aprepitant (Ap, n = 8) for 2 (a) or 4 (b, c) weeks. The level of expression of mRNA encoding CXCL13 (a, b) and CCL2 (c) in the dorsal root ganglia was determined by qPCR. Data is expressed as the mean ± SD and asterisks indicate statistically significant differences between the untreated and treated groups (p < 0.05)