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. 2017 Feb 1;12:8–17. doi: 10.1016/j.redox.2017.01.021

Fig. 3.

Fig. 3.

Hippocampal neurodegeneration in cognitively impaired Gpx4BIKO mice. A. Western blots showing levels of neural proteins synaptophysin (Syn), synaptosome associated protein-25 (SNAP), and NeuN, in cerebral cortex (CC) and hippocampus (HC) tissues of Gpx4BIKO mice with quantification (right), n=5. B. Nissl stained HC sections indicating neuronal loss in CA1 region (black arrows) in Gpx4BIKO mice with quantification representing average number of Nissl positive cells, n=3. C. Images of Fluoro-Jade C stained HC sections indicating degenerating CA1 neurons in Gpx4BIKO mice with quantification, n=3. * p<0.05; Control animals were Gpx4(f/f); tissues were collected after completion of behavioral tasks at 15 weeks post TAM treatment.