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Summary of biochemical changes in atheromas.
| Unstable | Stable | Stable/no Simvastatin | Stable/Simvstatin | |
|---|---|---|---|---|
| HIF-1α | ↑ | ↓ | ↓ | ↓↓ |
| ΝΟΧ-4 | ↑ | ↓ | ↓ | ↓ |
| ΗΟ-1 | ↑ | ↓ | ↓ | ↓↓ |
| iNOS | ↑ | ↓ | ↓ | ↓↓ |
| eNOS | ↓ | ↑ | ↑ | ↑↑ |
| phospho-eNOS (S1177) | ↓ | ↑ | ↑ | ↑↑ |
| Akt | – | – | – | – |
| phospho-Akt (S473) | ↓ | ↑ | ↑ | ↑ |
| sGC-α1 | ↓ | ↑ | ↑ | ↑ |
| sGC-β1 | ↓ | ↑ | ↑ | ↑ |
| CBS | ↑ | ↓ | ↓ | ↓ |
| CSE | ↑ | ↓ | ↓ | ↓↓ |
