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. 2017 Feb 1;27(1):36–44. doi: 10.1089/nat.2016.0627

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© Kazuhiko Haruta, et al., 2017; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 3. — Plasma concentration-time curves of sbC-PEGylated and conventionally PEGylated aptamers after their intravenous injection into mice. 17M-200-S1 that had been sbC-PEGylated with two 2-armed 40-kDa PEG (Y-shaped PEG, block) or conventionally PEGylated with various PEG (orange: SUNBRIGHT^® GL4-800GS2; yellow-green: SUNBRIGHT GL2-800GS2; yellow: SUNBRIGHT GL4-400GS2; green: SUNBRIGHT GL2-400GS2; blue: Y-shaped PEG) was intravenously administered to mice at a dose of 1 mg/kg. Three mice were used at each time point, and the data are expressed as mean ± SD values (n = 3).