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. 2017 Feb 1;27(1):36–44. doi: 10.1089/nat.2016.0627

FIG. 6.

FIG. 6.

In vivo neutralizing activity of anti-IL-17A aptamers. The IL-6 production induced in air pouches by human IL-17A was inhibited by the intraperitoneal administration of sbC-PEGylated 17M-382. The aptamers were administered to the mice at 1 h (A) or 24, 72, or 168 h (B) before the administration of human IL-17A into the air pouches. Data are expressed as mean ± SEM values (n = 7 or 8). **P < 0.01, ***P < 0.001 compared with the saline+IL-17A-treated group (ANOVA followed by Dunnett's test). ANOVA, analysis of variance.