Table 2.

Univariate and multivariate analyses of variables associated with overall survival

Variables	Univariate			Multivariate
	HR	95% CI	P a	HR	95% CI	P a
HCC patients
Gender (male/female)	1.333	0.747–2.377	0.331
HBV infection (no/yes)	0.863	0.431–1.729	0.678
Alpha-fetoprotein, ng/mL (≤25/>25)	1.023	1.003–1.043	0.027			NA
Child–Pugh class (A/B)	1.626	0.782–3.378	0.193
Histological grage (I/II/III/other)	1.42	0.901–2.237	0.131
Tumor number (single/multiple)	3.178	2.008–5.031	< 0.0001			NA
Tumor size, cm (≤5/>5)	1.838	1.154–2.927	0.01	1.614	0.997–2.613	0.051
Vascular invasion (absent/present)	3.832	1.825–8.046	< 0.0001	2.667	1.208–5.888	0.015
TNM stage (I vs. II + III)	3.383	2.164–5.289	< 0.0001	2.838	1.765–4.564	0.0002
$\text{CD2}{04}_{IT}^{+}$ cells (low/high)	1.922	1.217–3.034	0.005	2.125	1.298–3.478	0.003
${\text{CD169}}_{IT}^{+}$ cells (low/high)	0.561	0.358–0.878	0.011	0.436	0.270–0.703	0.001
GC patients
Gender (male/female)	1.189	0.702–2.013	0.52
Tumor size, cm (≤4/>4)	1.655	0.951–2.881	0.075
Tumor depth (pT1 + pT2 + pT3/pT4)	1.251	0.744–2.105	0.398
Lymph node metastasis (pN0 + pN1/pN2 + pN3)	1.999	1.192–3.353	0.009	2.012	1.178–3.437	0.011
TNM stage (I + II vs. III + IV)	2.031	1.103–3.738	0.023			NA
Histological grage (I/II/III/other)	1.18	0.772–1.804	0.445
$\text{CD2}{04}_{IT}^{+}$ cells (low/high)	1.033	0.625–1.709	0.899
${\text{CD169}}_{IT}^{+}$ cells (low/high)	0.569	0.343–0.943	0.029	0.587	0.354–0.974	0.039

Cox proportional hazards regression model; variables that were associated with overall survival in the univariate analysis were adopted as covariates in the multivariate analysis and were entered into the equation using the forward likelihood ratio method

HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis, CI confidence interval, NA not applicable, IT intra-tumor

^aItalic values indicate significance of p value (p < 0.05)