Table 3.
Association of Mφ with patients’ clinical characteristics
| Characteristics | CD204+ Mφsa | P b | CD169+ Mφsa | P b | ||
|---|---|---|---|---|---|---|
| Low | High | Low | High | |||
| HCC patients | ||||||
| Gender (male/female) | 73/19 | 81/10 | 0.104 | 75/19 | 81/10 | 0.105 |
| HBV infection (no/yes) | 7/85 | 11/80 | 0.333 | 8/86 | 11/83 | 0.629 |
| Alpha-fetoprotein, ng/mL (≤25/>25) | 42/50 | 30/61 | 0.096 | 36/58 | 38/56 | 0.881 |
| Child–Pugh class (A/B) | 85/7 | 85/6 | 1.000 | 89/5 | 86/8 | 0.567 |
| Tumor number (single/multiple) | 78/14 | 61/30 | 0.006 | 69/25 | 75/19 | 0.389 |
| Tumor size, cm (≤5/>5) | 48/44 | 28/63 | 0.004 | 38/56 | 42/52 | 0.658 |
| Vascular invasion (absent/present) | 87/5 | 85/6 | 0.767 | 88/6 | 89/5 | 1.000 |
| TNM stage (I/II + III) | 72/20 | 53/38 | 0.004 | 63/31 | 67/27 | 0.636 |
| Histological grade (I/II/III/other) | 71/21 | 50/41 | 0.002 | 68/26 | 57/37 | 0.122 |
| GC patients | ||||||
| Gender (male/female) | 45/21 | 51/14 | 0.237 | 45/21 | 50/16 | 0.439 |
| Tumor size, cm (≤4/>4) | 23/43 | 20/45 | 0.711 | 22/44 | 23/43 | 1.000 |
| Tumor depth (pT1 + pT2 pT3/pT4) | 20/46 | 21/44 | 0.852 | 22/44 | 24/42 | 0.855 |
| Lymph node metastasis (pN0 + pN1/pN2 + pN3) | 32/34 | 23/42 | 0.158 | 28/38 | 29/37 | 1.000 |
| TNM stage (I + II vs. III + IV) | 19/47 | 15/50 | 0.551 | 16/50 | 21/45 | 0.439 |
| Histological grade (I + II/III/other) | 19/42/5 | 14/45/4 | 0.637 | 22/37/6 | 13/49/4 | 0.112 |
HCC hepatocellular carcinoma, GC gastric cancer, HBV hepatitis B virus, TNM tumor-lymph node-metastasis
aData were missing for these variables in some patients: CD204+ Mφs, n = 183 and CD169+ Mφs, n = 188 in HCC; CD204+ Mφs, n = 131 and CD169+ Mφs, n = 132 in HCC
bItalic values indicate significance of p value (p < 0.05)