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In vivo magnetic resonance imaging analysis of heart function and left ventricle (LV) area. (A) LV surface area by 2 weeks of cold exposure. (B) LV surface area by 4 weeks of cold exposure. (C) LV surface area by 8 weeks of cold exposure. Data were calculated as fold changes of the pretreatment level. Data shown as means ± SEM; n = 8. *p < 0.05, **p < 0.01, ***p < 0.001 vs. warm-PBS group. +p < 0.05, ++p < 0.01 vs. the cold-SC-shRNA group.
