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AAV delivery ET1-shRNA attenuated the cold-induced increase in superoxide production. (A) In situ superoxide levels in the heart (red, DHE staining). (B) Quantification of superoxide levels. These parameters were measured at 10 weeks after exposure to cold. Data shown as means ± SEM; n = 8. **p < 0.01 vs. warm-PBS group. ++p < 0.05 vs. the cold-SC-shRNA group.
