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RNA-seq analysis of Dgcr8+/− and Dgcr8−/− NSCs. (A) Unsupervised clustering analysis of Dgcr8+/− and Dgcr8−/− NSCs. (B) GSEA demonstrated de-repression of transcription targets of miR-21 (left) and let-7 (right) in Dgcr8−/− NSCs. (C) GSEA demonstrated downregulation of genes associated with neuronal system, cell cycle, DNA replication, translation, and DNA repair in Dgcr8−/− NSCs. GSEA, gene set enrichment analysis. Color images available online at www.liebertpub.com/scd
