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. 2017 Feb 1;27(1):23–35. doi: 10.1089/nat.2016.0621

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© Gary A. Clawson, et al., 2017; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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FIG. 8. — Enhanced delivery of AP1153-bioconjugated CPSNPs to Orthotopic PDACs. Ex vivo imaging of whole tumor cross sections with multiphoton microscopy demonstrated the location of ICG-loaded CPSNPs (false colored in red) relative to collagenous fibrotic regions of the tumor (blue). (A) Mice bearing tumors and injected with CPSNPs without ICG (ghost particles) showed little background fluorescence. (B) Tumors from mice injected with untargeted ICG-CPSNPs (with no aptamer bioconjugation) had some minimal tumoral uptake over background. (C, D) Tumors from two separate mice injected with AP1153-targeted ICG-CPSNPs showed increased ICG signal throughout the tumor sections. A 50 μm scale bar is shown in the lower left corner of panel A. PDAC, pancreatic ductal adenocarcinoma.