Table 1.
Mammalian Redox-Regulated Transcription Factors
| Transcription Factor | Redox Regulator | Consequence |
|---|---|---|
| AP-1 | Trx-1, nucleoredoxin | Enhanced DNA binding |
| β-catenin | Trx-1,nucleoredoxin, Ref-1/APE | Enhanced DNA binding |
| Egr-1 | Ref-1/APE | Enhanced DNA binding |
| FOXO | Cys oxidation PTP1b | Block nuclear export |
| GR | Trx-1 | Enhanced DNA binding |
| HIF-1 | Trx-1, APE/Ref-1 | HIF-1 stability, HIF-1 activation |
| HSF1 | H2O2 | Altered DNA binding |
| TP53 | Trx-1, APE/Ref-1 | Enhanced DNA binding |
| NF-κB | Trx-1, APE/Ref-1 | Enhanced DNA binding |
| NRF2 | Trx-1 | Prevent degradation |
| Sp1 | Trx-1 | Enhanced DNA binding |
| TTF | APE/Ref-1 | Enhanced DNA binding |