Fig. 2.

Adipocyte function and examples of miRNA-mediated regulation. MiRNAs are involved in different steps of adipocyte maturation, metabolism and signaling. They regulate adipogenesis (positively: miR-17–92, miR375 and miR-146b; negatively: let-7 and miR-363), glucose uptake (miR-93 and miR-223), lipolysis and β-oxidation (miR-145), triglyceride synthesis (miR-125b), insulin signaling (miR-144), browning (miR-150 and miR-34a), adiponectin synthesis (miR-193b) and inflammation (miR-146b-5p in macrophages).