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. Author manuscript; available in PMC: 2018 Jan 20.
Published in final edited form as: Circ Res. 2017 Jan 20;120(2):278–281. doi: 10.1161/CIRCRESAHA.116.310194

Figure 1.

Figure 1

Milestones met (top) and challenges (middle) on the way to the clinical translation of myocardial re-muscularization by cardiomyocyte injection or implantation of tissue engineered myocardium. Suggested use of animal models in late preclinical development of myocardial re-muscularization (duration and animal number/study cohort; bottom). ATMP: advanced therapy medicinal product; ESC: embryonic stem cell; GLP: good laboratory practice; GMP: good manufacturing practice; IND: investigational new drug; iPSC: induced pluripotent stem cell; RNU: Rowett Nude