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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Pediatr Surg. 2016 Aug 5;51(11):1812–1817. doi: 10.1016/j.jpedsurg.2016.07.015

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Disease-specific survival according to age, microsatellite genotype and microsatellite genotype in relation to BRAF mutational status. a. Disease-specific survival of early-age onset colorectal cancer compared to adult onset colorectal cancer patients. 5-year disease-specific survival in the early-age onset group is worse compared to the adult onset group (48% vs. 78%, P<0.001). b. Disease-specific survival in adult-age onset colorectal cancer patients according to microsatellite instability (MSI) and microsatellite stability (MSS). MSI genotype was associated with a favorable 5-year disease-specific survival (93% vs. 73%, P=0.006). c. Disease-specific survival in early-age onset colorectal cancer patients according to microsatellite instability (MSI) and microsatellite stability (MSS). MSI genotype was associated with a favorable 5-year disease-specific survival (65% vs. 39%, P=0.048). d. Disease-specific survival in early-age onset group with microsatellite stability (MSS) phenotype stratified according to BRAF mutational status. 5-year disease-specific survival trended worse in patients possessing the MSS/BRAFV600Emut genotype compared to the MSS/BRAF wild-type (WT) genotype (16% vs. 42%, p=0.23). e. Disease-specific survival of adult onset-MSI genotype compared to early-age onset-MSI genotype in colorectal cancer patients. Both adult and early-age onset MSI were associated with favorable survivals, though adult-MSI genotype was associated with a more favorable 5-year disease-specific survival (93% vs. 65%, P=0.01).