TABLE 1.

Clinical and molecular features of early onset and adult onset colorectal cancer

Characteristics	Early Onset (N=94)	Adult Onset (N=275)	P
Median age, years	27	67	---
Sex: Males	45 (48)	146 (55)	NS
Family History of Colorectal Cancer	40 (43)	74 (27)	NS
Amsterdam II	5 (5)	2 (<1)	NS
Location: Proximal	32 (34)	96 (35)	NS
Stage: III/IV	71 (76)	140 (46)	<0.0001
Histology: Signet ring-cell	12 (13)	3 (1)	<0.0001
Poorly differentiated	35 (37)	22 (8)	<0.0001
5-year disease-specific survival	48%	78%	<0.0001
MSI	25 (27)	36 (13)	<0.01
BRAFV600E mutation	8 (9)	22 (8)	NS
KRAS codon 12/13 mutation	26 (28)	99 (36)	NS

MSI - Microsatellite instability

Data are expressed as No. (%) unless otherwise noted