TABLE 2.

Cox regression

	Unadjusted Analyses				Adjusted Analyses
	Hazard Ratio	95% Lower limit	95% Upper limit	P Value	Hazard Ratio	95% Lower limit	95% Upper limit	P Value
Early onset vs. Adult onset	2.52	1.75	3.65	<.0.001	1.96	1.29	2.98	0.002
Muc or SRC Status				0.04				0.73
Not SRC or Muc vs. Muc	1.22	0.69	2.14	0.49	1.12	0.63	2.00	0.70
SRC vs. Muc	3.05	1.23	7.60	0.02	1.58	0.51	4.85	0.42
Stage Status: I/II vs. III/IV	0.16	0.10	0.25	<.0.001	0.18	0.11	0.29	<.0.001
Grade Status: PD vs. MD or WD	1.75	1.11	2.75	0.02	1.20	0.67	2.15	0.54
KRAS status: WT vs. Mut	0.59	0.41	0.83	0.003	0.57	0.40	0.83	0.003
MSS vs. MSI	0.43	0.23	0.83	0.01	0.42	0.22	0.83	0.01
BRAF status: WT vs. Mut	0.82	0.40	1.69	0.59
Location status: Prox vs. Dis	1.15	0.79	1.67	0.48
Family history (Yes vs. No)	1.38	0.90	2.11	0.14
Sex status: Male vs. Female	1.17	0.83	1.67	0.37

MSI - microsatellite instability, MSS - microsatellite stability, Muc – mucinous, SRC – signet ring cell, PD – poor differentiation, MD – moderate differentiation, WD – well differentiation, WT – wild type, Mut – mutation, Prox – proximal colon, Dis – distal colon