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. Author manuscript; available in PMC: 2017 Nov 1.

Published in final edited form as: J Pediatr Surg. 2016 Aug 5;51(11):1812–1817. doi: 10.1016/j.jpedsurg.2016.07.015

TABLE 3.

Genetic subgroups defined by MSI and B-rafV600E status

Genotype		Early Onset (N=94)	Adult Onset (N=275)	P
	BRAF mut	0 (0%) Stage III/IV: - 5-yr DSS: -	14 (38%) Stage III/IV: 93% 5-yr DSS: 100%
MSI				<0.001
	BRAF WT	25 (100%) Stage III/IV: 72% 5-yr DSS: 65%	23 (62%) Stage III/IV: 65% 5-yr DSS: 90%

	BRAF mut	8 (12%) Stage III/IV: 100% 5-yr DSS: 16%	8 (3%) Stage III/IV: 100% 5-yr DSS: 75%
MSS				<0.01
	BRAF WT	61 (88%) Stage III/IV: 72% 5-yr DSS: 42%	230 (97%) Stage III/IV: 53% 5-yr DSS: 75%

MSI – microsatellite instability, MSS – microsatellite stability