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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: J Pediatr Surg. 2016 Aug 5;51(11):1812–1817. doi: 10.1016/j.jpedsurg.2016.07.015

TABLE 4.

Clinical, histologic and molecular features in relation to primary tumor location

Age group Location
(%)		 N Sex: M/F Advanced
Stage (%)		 Well/Moderate
Differentiated
(%)		 MSI (%) BRAF (%) KRAS
(%)		 Median
OS3 		5-year
overall
survival
Early Onset Proximal 30 13/17 23 (77%) 16 (53%) 9 (30%) 3 (10%) 6 (20%) 43 month 40%6
Distal 58 27/31 43 (74%) 38 (66%) 14 (24%) 4 (7%) 19 (33%) 56 month 48%7
Adult Onset Proximal 96 56/40 49 (51%) 78 (81%) 24 (25%)1 15 (16%)2 35 (36%) NA4 70%6
Distal 179 94/85 85 (47%) 156 (87%) 13 (7%)1 7 (4%)2 64 (36%) NA5 81%7
1

Chi-square p <0.0001;

2

p=0.0006;

3

both p=0.13 for comparing proximal to distal in each age group;

4

25% failure time was 45 month;

5

25% failure time was 80 month;

6

Chi-square p <0.09 comparing proximal location in early onset vs adult onset;

7

Chi-square p<0.0001 comparing distal location in early onset vs. adult onset