Fig. 3.

Truncation of Cx43 results in a cortical phenotype with increased cross-sectional area, increased cortical porosity, cortical thinning and marrow cavity expansion in 6-week-old male Gja1^−/K258Stop mice. (A) Top, cross section through the femoral mid-diaphysis from a representative microCT slice from Gja1^+/− and Gja1^−/K258Stop mice. Bottom, 3D reconstruction of intact femurs. (B) Quantification of the cortical phenotype at the femoral mid-diaphysis by microCT (n=11 for Gja1^+/− and n=8 for Gja1^−/K258Stop); see Materials and Methods for the definitions of the parameters. Graphs depict mean±s.d. *P<0.05 (two-tailed t-test).