Table 3.
Supplemental Information on Cardiometabolic Diseases and Fatigue Syndromes
| Disease | Supplement | Probiotic Strain(s) |
|---|---|---|
| Dyslipidemia | Advanced Multi-Billion Dophilus (Solgar) | Lactobacillus GG |
| Dyslipidemia | Digestive Health Probiotic (Nature Made) | L plantarum 299V |
| Dyslipidemia | Heart Healthy Probiotic Solutions (Dr Sinatra) | L plantarum 299V |
| Dyslipidemia | Jarrow Formulas Ideal Bowel Support | L plantarum 299V |
| Dyslipidemia | Pro-B (Rephresh) | L rhamnosus GR-1 |
| Dyslipidemia | Probiata Digestion Support and Critical Care (Kyolic) | L plantarum 299V |
| Dyslipidemia | Probiotic Balance (Sundown Naturals) | L plantarum 299V |
| Dyslipidemia | Probiotic GX (Nature’s Bounty) | L plantarum 299V |
| Dyslipidemia | Probiotic Supplement (GoodBelly) | L plantarum 299V |
| Dyslipidemia | UltraFlora Women’s (Metagenics) | L rhamnosus GR-1 |
| Dyslipidemia | Walgreens Probiotic Lactobacillus GG | Lactobacillus GG |
| Dyslipidemia | Women’s Fem Dophilus (Jarrow Formulas) | L rhamnosus GR-1 |
| Fatigue syndrome | Align Probiotic Digestive Care (Proctor & Gamble) | B infantis 35624 |
| Fatigue syndrome | Digestive Health Probiotic (Nature Made) | L plantarum 299V |
| Fatigue syndrome | Gene-filus F19 (Siffra Farmaceutici) | L paracasei sbsp paracasei F19 |
| Fatigue syndrome | Heart Healthy Probiotic Solutions (Dr Sinatra) | L plantarum 299V |
| Fatigue syndrome | Isolated for research purposes only | F prausnitzii |
| Fatigue syndrome | Jarrow Formulas Ideal Bowel Support (10 Billion) Organisms V-Capsules | L plantarum 299V |
| Fatigue syndrome | Not available | L casei strain Shirota (Yakult Honsha, Tokyo, Japan) |
| Fatigue syndrome | Not Available | B fragilis |
| Fatigue syndrome | Not available |
B breve Yalult L casei Shirota |
| Fatigue syndrome | Probiata Digestion Support and Critical Care (Kyolic) | L plantarum 299V |
| Fatigue syndrome | Probiotic Acidophilus BioBeads (Natrol, Inc) | L acidophilus-loaded alginate beads |
| Fatigue syndrome | Probiotic Balance (Sundown Naturals) | L plantarum 299V |
| Fatigue syndrome | Probiotic GX (Nature’s Bounty) | L plantarum 299V |
| Fatigue syndrome | Probiotic Supplement (GoodBelly) | L plantarum 299V |
| Fatigue syndrome | Securil (Nutricology ) | P freudenreichii |
| Fatigue syndrome | Theralac Probiotic (Master Supplements) | L acidophilus alginate |
| Fatigue syndrome | TruBiotics (Bayer) | B lactis BB-12 |
| Fatigue syndrome | Ultraflora Balance (Metagenics) | L acidophilus NCFB 1748 |
| Fatigue syndrome | Widely available in dietary supplements | Lactobacillus species |
| Gout | Isolated and colonized from Chinese sauerkrauts for research purposes (not commercially available | Strain DM9218 (analysis of this strain 16S rRNA sequences showed that DM9218 has the highest similarity [99%] to Lactobacillus plantarum WCFS1) |
| NAFLD | BIFIDO DIGEST 60C (F) (Protocol for Life) | S thermophilus |
| NAFLD | Isolated - cultured in brain, heart under anaerobic conditions for research purposes | B adolescentis |
| NAFLD | Isolated for research purposes only | L curvatus HY7601 alone or in combination with L plantarum KY103 |
| NAFLD | Isolated from healthy volunteers’ fresh feces for research purposes | Bifidobacteria L66-5, L75-4, M13-4, and FS31-12 |
| NAFLD | NOW Foods Probiotic (10 50 Billion) | S thermophilus |
| NASH/NAFLD | Advanced Multi-Billion Dophilus (Solgar) | L rhamnosus GG (1.2109 CFU/d) |
| NASH/NAFLD | Dr Ohhira’s Probiotics Original Formula | L bulgaricus, S thermophilus (5.01011 CFU/d) |
| NASH/NAFLD | MegaFood (MegaFlora) | L bulgaricus, S thermophilus (5.01011 CFU/d) |
| NASH/NAFLD | ProSynbiotic (Standard Process) | L acidophilus LA-5, B breve subsp lactis BB-12 |
| NASH/NAFLD | TruBiotics (Bayer) | L acidophilus LA-5, B breve subsp lactis BB-12 |
| NASH/NAFLD | Walgreens Probiotic Lactobacillus GG | L rhamnosus GG (1.2109 CFU/d) |
| NASH/NAFLD | Widely available (found in most probiotic formulas) | B thermophilus, L thermophilus, S thermophilus |
| Obesity | BIFIDO DIGEST 60C (F) (Protocol for Life) | S thermophilus |
| Obesity | Enterogenic Concentrate (Integrative Therapeutics) | E faecium |
| Obesity | GoLive Probiotic & Prebiotic Drink Mix | L salivarius LS-33 |
| Obesity | Health-Bac 100 grams (North American Herb & Spice) | E faecium |
| Obesity | Hyper-Implante (InterPlexus) | L salivarius LS-33 |
| Obesity | Isolated - cultured in brain, heart under anaerobic conditions for research purposes | B adolescentis |
| Obesity | Isolated for research and not commercially available - prepared with lactic acid bacteria starter cultures (Streptococcus thermophilus and Lactobacillus delbrueckii ssp. bulgaricus) commonly used for conventional yogurt production and viable cells of LG2055 | L gasseri SBT-2055, L gasseri LG-2055 (51010 CFU) |
| Obesity | Isolated for research purposes only | L curvatus HY-7601 alone or in combination with L plantarum KY-1032 |
| Obesity | Isolated for research, from the GI of health Estonian children, and not commercially available | L plantarum TENSIA (1.51011 CFU/g added to cheese milk before renneting) |
| Obesity | Isolated from healthy volunteers’ fresh feces for research purposes | Bifidobacteria L66-5, L75-4, M13-4, and FS31-12 |
| Obesity/T2DM | Isolated from stool for research purposes. | B adolescentis |
| Obesity | Nature’s Secret Ultimate Probiotic (4 billion) | E faecium |
| Obesity | Probiotic Supreme DF (Designs for Health) | L salivarius LS-33 |
| Obesity | ProSynbiotic (Standard Process) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| Obesity | ProSynbiotic (Standard Process) |
L acidophilus LA-5, B lactis BB-12 L casei DN001 (108 CFU/g) |
| Obesity | ProSynbiotic (Standard Process) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| Obesity | TruBiotics (Bayer) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| Obesity | TruBiotics (Bayer) | L acidophilus LA-5, B lactis BB-12, L casei DN001 (108 CFU/g) |
| Obesity | TruBiotics (Bayer) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| Obesity | Ultimate Intestinal Shield (Phyto Therapy) | L salivarius LS-33 |
| Obesity | UltraFlora Spectrum (Metagenics) | L salivarius LS-33 |
| Obesity/NAFLD | Florastor (Biocodex) | S boulardii (Biocodex) |
| Obesity/NAFLD | Strengtia (Apex Energetics) | S boulardii |
| Obesity/NAFLD | Designs for Health | S boulardii |
| Obesity/NAFLD | Isolated for research purposes (plant derived) | L plantarum SN13T as comparator |
| Obesity/NAFLD | Isolated from feces of exclusively breast (fed infants for research purposes) | L paracasei CNCM I-4034, B breve CNCM I-403, L rhamnosus (CNCM or mixture of 3 strains) |
| Obesity/NAFLD | Isolated from longan fruit (Euphoria longana) for research purposes | P pentosaceus LP28 |
| Obesity/NAFLD | Isolated for research purposes only | L paracasei CNCM I-4270, L rhamnosus I-3690, B animalis subsp lactis I-2494 |
| Obesity/NAFL/T2DM | Advanced Multi-Billion Dophilus (Solgar) | L rhamnosus GG |
| Obesity/NAFLD/T2DM | Isolated from stool for research purposes | Lactic acid bacterium supplement (B pseudocatenulatum SPM-1204, B longum SPM-1205, B longum SPM-1207 (108–109 CFU) |
| Obesity/NAFL/T2DM | Walgreens Probiotic Lactobacillus GG | L rhamnosus GG |
| Obesity/T2DM/NAFLD | Isolated and obtained from National Collection of Dairy Cultures for research purposes. | L lactis |
| Obesity/T2DM/NAFLD | Isolated from stools of healthy infants (mean age, 5.7 y; range, 1.0–10.8 y) for research purposes | B uniformis CECT 7771 |
| Obesity/T2DM/NAFLD | Not available | Acetobacter |
| O Obesity/T2DM/NAFLD | Securil (Nutricology) | Propionibacterium |
| PCOS | Flora8 (PromoPharma) | Bifidobacteria and Lactobacterium combined with prebiotic food source (inulin, fructose oligosaccharide) |
| PCOS | Probiotic + Prebiotic Flora Renew (Family Flora) | Bifidobacteria and Lactobacterium combined with prebiotic food source (inulin, fructose oligosaccharide) |
| PCOS | Sunbiotics Potent Probiotics with Organic Prebiotics Powder | Bifidobacteria and Lactobacterium combined with prebiotic food source (inulin, fructose oligosaccharide) |
| T2DM | BIFIDO DIGEST 60C (F) (Protocol for Life) | S thermophilus |
| T2DM | Not available | Roseburia |
| T2DM | Not available | E halii |
| T2DM | NOW Foods Probiotic (10 50 Billion) | S thermophilus |
| T2DM | ProSynbiotic (Standard Process) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| T2DM | ProSynbiotic (Standard Process) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| T2DM | TruBiotics (Bayer) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| T2DM | TruBiotics (Bayer) | L acidophilus LA-5, B animalis subsp lactis BB-12 |
| T2DM | Not available | F prauznitzii |
| T2DM | ProSynbiotic (Standard Process) | L acidophilus LA-5, B lactis BB-12 combination |
| T2DM | Provided in probiotic soy milk | L plantarum A7 |
| T2DM | TruBiotics (Bayer) | L acidophilus LA-5, B lactis BB-12 combination |
Abbreviations: NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis; T2M, type 2 diabetes mellitus; PCOS, polycystic ovary syndrome.