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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Cancer Discov. 2017 Feb;7(2):131–133. doi: 10.1158/2159-8290.CD-16-1423

Figure 1.

Figure 1

Schematic illustration of Ras and NF-κB activation through epigenomic down regulation of the Ras-GAP proteins RASAL2 and DAB2IP in luminal B breast cancer to drive invasion and metastasis. Both RASAL2 and DAB2IP contain RasGAP domains while DAB2IP has an additional Period-like domain that binds TRAF2 to inhibit NF-κB.