Fig 6. Inhibition of the edematogenic activity of B. jararaca venom (BjV) by extracts of K. brasiliensis (Kb) (A) and K. pinnata (Kp) (B) in pre-treatment protocol.

BjV was injected i.pl. in the right hind paw of mice pre-treated i.p. with different extracts. Paw thickness was measured during 120 min after venom injection. Edema was expressed as the increase in paw thickness calculated as the percentage difference between the paw thickness after (at respective time) and before (basal values) venom injection. The points represent the mean ± SEM (n = 5). *p<0.05, **p<0.01 and ***p<0.001 compared to the group receiving venom alone along with the i.p. injection of 5% castor oil in PBS (Two-way ANOVA followed by the Bonferroni test).