Table 4. Equilibrium Dissociation Constants Determined by SPR for the Interaction of Enfuvirtide from Monolayers (HPA Chip) and Bilayers (L1 Chip)*.
Lipid | KD±SE**(×10−6 M) | KD monolayer/KD bilayer | |
---|---|---|---|
Monolayer | Bilayer | ||
POPC | 5.83±1.1 | 11.3±1.9 | 0.52 |
POPC:DPPC(1:1) | 1.39±1.1 | 4.41±1.8 | 0.32 |
POPC:DPPC(1:2) | 3.28±3.0 | 4.34±1.8 | 0.75 |
DPPC | 5.69±3.9 | 3.93±2.6 | 1. 5 |
EPC | 11.6±2.1 | 43.0±9.0 | 0.27 |
SM | 163±78 | 6.98±1.6 | 23 |
*Calculated by Derived According to a Steady-State Affinity Model.
**Standard Error.