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. Author manuscript; available in PMC: 2018 Feb 3.
Published in final edited form as: Circ Res. 2017 Feb 3;120(3):449–471. doi: 10.1161/CIRCRESAHA.116.308427

Figure 1. Risk factors and end-organ effects of vascular disease.

Figure 1

Schematic illustration of leading risk factors for large and small vessel disease and stroke as well as key changes in vascular function, the BBB, atherosclerosis, and vascular structure. The lower portion of the figure illustrates progression vascular disease over time with major end-organ effects.