Table 1.
Baseline Characteristics in the N0574 Trial
| Characteristics | SRS Alone (n = 111) |
SRS Plus WBRT (n = 102) |
|---|---|---|
| Age, mean (SD), y | 59.8 (10.4) | 61.4 (10.6) |
| Age group, y, No. (%) | ||
| 18 to 59 | 53 (47.7) | 44 (43.1) |
| ≥60 | 58 (52.3) | 58 (56.9) |
| Sex, No. (%) | ||
| Female | 57 (51.4) | 46 (45.5) |
| Male | 54 (48.6) | 55 (54.5) |
| Race, No. (%) | ||
| White | 95 (86.4) | 85 (83.3) |
| Nonwhite | 15 (13.6) | 17 (16.7) |
| Months of systemic disease control, No. (%) |
||
| ≤3 | 81 (73.0) | 75 (73.5) |
| >3 | 30 (27.0) | 27 (26.5) |
| No. of brain metastases, No. (%) | ||
| 1 | 55 (49.5) | 56 (54.9) |
| 2 | 39 (35.1) | 36 (35.3) |
| 3 | 17 (15.3) | 10 (9.8) |
| ECOG performance score, No. (%)a | ||
| 0 | 49 (44.5) | 49 (48.0) |
| 1 | 50 (45.5) | 45 (44.1) |
| 2 | 11 (10.0) | 8 (7.8) |
| Primary tumor site, No. (%) | ||
| Breast | 11 (9.9) | 7 (6.9) |
| Colorectal | 7 (6.3) | 4 (4.0) |
| Lung | 80 (72.1) | 66 (65.3) |
| Skin/melanoma | 3 (2.7) | 9 (8.9) |
| Bladder | 1 (0.9) | 1 (1.0) |
| Kidney | 1 (0.9) | 4 (4.0) |
| Gynecologic | 2 (1.8) | 3 (3.0) |
| Other | 6 (5.4) | 7 (6.9) |
| Cranial nerves, No. (%) | ||
| Normal | 102 (91.9) | 92 (91.1) |
| Abnormal | 9 (8.1) | 9 (8.9) |
| Sensation, No. (%) | ||
| Normal | 105 (94.6) | 96 (96.0) |
| Abnormal | 6 (5.4) | 4 (4.0) |
| Motor, No. (%) | ||
| Normal | 97 (87.4) | 89 (88.1) |
| Abnormal | 14 (12.6) | 12 (11.9) |
| Cerebellar, No. (%) | ||
| Normal | 92 (82.9) | 85 (84.2) |
| Abnormal | 19 (17.1) | 16 (15.8) |
| FACT-Br total score, mean (SD)b | 146.6 (24.0) | 141.7 (27.7) |
| Cognitive test scores, mean (SD)c | ||
| HVLT-R | ||
| Immediate recall | −1.4 (1.4) | −1.7 (1.3) |
| Delayed recall | −1.3 (1.8) | −1.6 (1.7) |
| Recognition | −0.8 (1.9) | −0.9 (1.8) |
| TMT-A time to complete | −1.7 (3.6) | −1.9 (3.1) |
| TMT-B time to complete | −2.8 (4.3) | −3.2 (4.3) |
| COWAT total | −1.0 (1.2) | −1.1 (1.2) |
| GPS total, mean (SD), s | −6.2 (8.6) | −5.4 (6.0) |
Abbreviations: COWAT, Controlled Oral Word Association Test; ECOG, Eastern Cooperative Oncology Group; FACT-Br, Functional Assessment of Cancer Therapy–Brain; GPS, Grooved Pegboard Test; HVLT-R, Hopkins Verbal Learning Test–Revised; SRS, stereotactic radiosurgery; TMT, Trail Making Test; WBRT, whole brain radiotherapy.
ECOG performance status scores range from 0 to 5, with higher numbers indicating greater disability; a score of 0 indicates no symptoms; 1, mild symptoms; and 2, symptomatic (<50% in bed during the day).
FACT-Br scores range from 0 to 200; higher scores indicate better quality of life.
Cognitive tests are reported as standardized scores (z scores, transformed so that higher scores indicate better cognitive performance): (patient value − published-norm mean value)/published-norm standard deviation value.