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. 2017 Feb 23;2(4):e88226. doi: 10.1172/jci.insight.88226

Figure 6. Multiple parameter analysis.

Figure 6

(A–E) Graphs show correlations across each pair of independently assessed Ab functions in VC and CIP using Spearman’s rank correlations. (F) The cumulative β deviation of VCs (blue) or HIV– (gray) from CIPs, which are represented by the vertical line at 0.0. (G) Hierarchical clustering of patient IgG profiles using a dendrogram heat map, incorporating Ab binding, neutralization, and FCGR signaling. The heat map displays the percentile rank of Ab parameters for each patient. Colored bars along the bottom define IgG parameter that correspond to patient group. *P > 0.05, **P > 0.01, ***P > 0.005. Significance of patients IgG cluster profiles of greater then 3 patients are shown. For univariate and multivariate analysis, P values were calculated using MANOVA in R using the Hotelling-Lawley analysis to find the significance of the model. Correlations between the interrelatedness of 2 Ab functions were calculated using Spearman rank tests. Clustering of patients and IgG properties were based on pair-wise Euclidean distance measurements. Significance was calculated using the multiscale bootstrap resampling.