Table 1.

Candidate antigen presenting cells for CD8+ T cells in toxoplasma-infected brain

Cell Type	Description	References	Disease model
Neurons	CD8+ T cells damage neuronal axons in an MHC I dependent manner in vivo global elevation in MHC I expression during infection Toxoplasma cysts are exclusively observed in neurons	[75] [46] [12]	EAE cerebral LCMV chronic T. gondii
Astrocytes	CD8+ T cells are capable of forming immunological synapses with astrocytes in vivo mice with astrocytes lacking cytokine receptor gp130 succumb to infection	[47] [48] [76]	adenovirus infection chronic T. gondii
Microglia	CD8+ T cells observed in contact with CD11c+ cells in brain parenchyma Microglia first to take up antigen during disease progression	[15] [77]	chronic T. gondii EAE
Infiltrating/Perivascular phagocytes	CD8+ T cells observed in contact with CD11c+ cells in the brain parenchyma MHC I elevated in vasculature of brain CD8+ T cells interact with perivascular APCs Perivascular MHC I dependent proliferation of CD8+ T cells	[15] [46] [45] [44] [43]	chronic T. gondii cerebral LCMV EAE cerebral LCMV