FIGURE 7.
Elevated expression of c-FLIPL and TIP49 correlated with cell growth in lung cancer cells. Gene expression analysis of c-FLIPs/L and TIP49 in Oncomine datasets showed an increase in expression in lung cancers versus normal lung. Data were collected from TCGA Lung2 (A) and Landi Lung (B). C, c-FLIPL and TIP49 expressions were detected by immunohistochemical analysis on specimens of patients with lung cancer. Representative images were shown on adjacent histologically non-tumor tissue and tumor tissue. The expression levels were measured by Image-Pro Plus software and quantitative analysis shown in the diagram. D, the protein levels of c-FLIPL and TIP49 were examined in six lung cancer cell lines. According to the expression level, cells were divided into two groups: low expression as Group I and high expression as Group II. E, cell growth of various lung cancer cell lines was determined by the RTCA method.