Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic of the role of DOCK8 in leukocyte migration. In this model, DOCK8 functions not only as a Cdc42 GEF but also as a scaffold protein that links Cdc42 activation to actomyosin dynamics through its interaction with LRAP35a. KIM, kinase inhibitory motif; CRIB, Cdc42/Rac-interactive binding site.
