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Fertility is impaired in cKO mice. Control and cKO males (n = 6 or 4) and females (n = 4) were paired with wild-type C57BL6 mice for 6 or 4 months, respectively. A and B, average number of litters (A) and litter size (B) in control and cKO males. Different colors are used to indicate data from individual animals. C, average litter size in control and cKO females.
